| CAT # | Khoom npe | Kev piav qhia |
| PEB 3611 | SIB-204990 | SB-204990 yog prodrug ntawm lub zog ATP citrate-lyase inhibitor SB-201076. SB-204990, thaum siv qhov ncauj rau nas, tau nqus mus rau hauv cov kab ke hauv lub cev, cov tshuaj muaj feem cuam tshuam ntawm SB-201076 tau zoo nyob hauv daim siab. SB-204990 (25 mg / kg ib hnub) kuj txo cov roj cholesterol hauv ntshav (txog 23%) thiab qib triglyceride (txog 38%) hauv tus dev, nyiam txo qis lipoprotein tsawg dua piv nrog cov lipoprotein cholesterol siab. qib. SB-204990 yog ib qho enzyme tseem ceeb hauv kev tswj cov substrate mov rau lipid synthesis de novo thiab lub peev xwm enzyme lub hom phiaj rau kev cuam tshuam hypolipidaemic. |
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