| CAT # | Khoom npe | Kev piav qhia |
| PIB 100603 | TIAB SA 36122 | MDK36122, tseem hu ua H-PGDS Inhibitor I, yog Prostaglandin D Synthase (hematopoietic-type) Inhibitor. MDK36122 tsis muaj npe, thiab muaj CAS # 1033836-12-2. Tus lej 5 kawg tau siv rau lub npe rau kev sib txuas lus yooj yim. MDK36122 xaiv blocks HPGDS (IC50s = 0.7 thiab 32 nM hauv enzyme thiab cellular assays, ntsig txog) nrog kev ua haujlwm me me tawm tsam tib neeg cov enzymes L-PGDS, mPGES, COX-1, COX-2, thiab 5-LOX. |
| PIB 100602 | Tepoxalin | Tepoxalin, tseem hu ua ORF-20485; RWJ-20485; yog 5-lipoxygenase inhibitor muaj peev xwm kho mob hawb pob, osteoarthritis (OA). Tepoxalin muaj nyob rau hauv vivo inhibitory kev ua ub no tiv thaiv COX-1, COX-2, thiab 5-LOX hauv cov dev ntawm qhov kev pom zoo tam sim no noj. Tepoxalin txhim kho kev ua haujlwm ntawm cov tshuaj tua kab mob antioxidant, pyrrolidine dithiocarbamate, hauv kev txo qis qog necrosis yam alpha-induced apoptosis hauv WEHI 164 hlwb. |
| PIB 100601 | Tenidap | Tenidap, tseem hu ua CP-66248, yog COX / 5-LOX inhibitor thiab cytokine-modulating anti-inflammatory tus neeg sib tw uas tab tom txhim kho los ntawm Pfizer raws li kev cog lus muaj peev xwm kho mob rheumatoid mob caj dab, tab sis Pfizer nres kev txhim kho tom qab kev pom zoo kev lag luam raug tsis lees paub. los ntawm FDA nyob rau hauv 1996 vim lub siab thiab lub raum toxicity, uas yog ntaus nqi rau metabolites ntawm cov tshuaj nrog thiophene moiety uas ua rau oxidative puas tsuaj. |
| PIB 100600 | PF-4191834 | PF-4191834 yog ib qho tshiab, muaj zog thiab xaiv tsis-redox 5-lipoxygenase inhibitor zoo hauv kev mob thiab mob. PF-4191834 nthuav tawm lub zog zoo hauv enzyme- thiab kev soj ntsuam ntawm tes, nrog rau hauv cov qauv nas ntawm tus mob mob. Enzyme assay cov txiaj ntsig qhia tias PF-4191834 yog lub zog 5-LOX inhibitor, nrog IC (50) = 229 +/- 20 nM. Tsis tas li ntawd, nws pom tau hais tias kwv yees li 300-fold selectivity rau 5-LOX tshaj 12-LOX thiab 15-LOX thiab qhia tias tsis muaj kev cuam tshuam rau cov enzymes cyclooxygenase. Tsis tas li ntawd, PF-4191834 inhibits 5-LOX hauv tib neeg cov ntshav, nrog IC (80) = 370 +/- 20 nM. |
| PAB 100599 | TSI-886 | MK-886, tseem hu ua L 663536, yog leukotriene antagonist. Nws tuaj yeem ua qhov no los ntawm kev thaiv cov 5-lipoxygenase activating protein (FLAP), yog li inhibiting 5-lipoxygenase (5-LOX), thiab tuaj yeem pab kho atherosclerosis. MK-886 inhibits cyclooxygenase-1 kev ua haujlwm thiab inhibits platelet aggregation. MK-886 induces kev hloov hauv lub voj voog ntawm tes thiab nce apoptosis tom qab photodynamic kho nrog hypericin. MK-886 txhim kho qog necrosis yam-alpha-induced sib txawv thiab apoptosis. |
| PAB 100598 | L-691816 | L 691816 yog ib qho muaj zog inhibitor ntawm 5-LO cov tshuaj tiv thaiv ob qho tib si hauv vitro thiab ntau yam hauv vivo qauv. |
| PAB 100597 | TSI-977 | CMI-977, tseem paub tias yog LPD-977 thiab MLN-977, yog lub zog 5-lipoxygenase inhibitor uas cuam tshuam rau kev tsim cov leukotrienes thiab tam sim no tau tsim los kho mob hawb pob. CMI-977 inhibits 5-lipoxygenase (5-LO) cellular o txoj hauv kev los thaiv cov tiam ntawm leukotrienes, uas ua lub luag haujlwm tseem ceeb hauv kev ua rau mob hawb pob bronchial. |
| PIB 100596 | CJ-13610 | CJ-13610 yog ib qho active inhibitor ntawm 5-lipoxygenase (5-LO). CJ-13610 inhibits biosynthesis ntawm leukotriene B4 thiab tswj IL-6 mRNA qhia hauv macrophages. Nws muaj txiaj ntsig zoo hauv cov qauv ua ntej ntawm qhov mob. |
| PAB 100595 | BRP-7 | BRP-7 yog 5-LO activating protein (FLAP) inhibitor. |
