Ingliforib

Lub npe tshuaj:

5-chloro-N-((2S,3R)-4-((3S,4R)-3,4-dihydroxypyrrolidin-1-yl)-3-hydroxy-4-oxo-1-phenylbutan-2-yl)- 1H-indole-2-carboxamide

SMILES Code:

O[C@H](C1)[C@@H](O)CN1C([C@H](O)[C@H](CC2=CC=CC=C2)NC(C3=CC4=C( N3)C=CC(Cl)=C4)=O)=O

InChi Code:

InChI = 1S/C23H24ClN3O5/c24-15-6-7-16-14(9-15)10-18(25-16)22(31)26-17(8-13-4-2-1-3- 5-13) 21(30)23(32)27-11-19(28)20(29)12-27/h1-7,9-10,17,19-21,25,28-30H,8, 11-12H2,(H,26,31)/t17-,19-,20+,21+/m0/s1

InChi Key:

GVDRRZOORHCTAN-MJUUVYJYSA-N

Lo lus tseem ceeb:

Ingliforib; CP-296; CP-368; CP-368,296; pwm 296; CP 296; CP-368296; CP368296; TIAB SA 368296

Solubility:DMSO

Cia: 

Nqe lus piav qhia:

Ingliforib, tseem hu ua CP-368296, yog ib qho tshiab glycogen phosphorylase inhibitor. Ingliforib muaj antihyperglycemic thiab cardioprotective zog. Ingliforib inhibits glycogen phosphorylase, tus nqi txwv enzyme hauv glycogenolysis, yog li tiv thaiv kev tso tawm ntawm cov piam thaj-1 phosphate los ntawm glycogen molecule hauv daim siab. Tus neeg sawv cev no tseem inhibits glycogen phosphorylase hauv cov leeg nqaij thiab tuaj yeem tiv thaiv lub plawv los ntawm myocardial ischemic raug mob los ntawm kev khaws cov ntsiab lus glycogen thiab txhim kho glycolytic-oxidative coupling.

Hom phiaj: glycogen phosphorylase