GDC6036; GDC6036 atropisomers

Lub npe tshuaj:

2-Propen-1-ib, 1-[(3S)-4-[7-[6-amino-4-methyl-3-(trifluoromethyl)-2-pyridinyl]-6-chloro-8-fluoro-2- [[(2S)-1-methyl-2-pyrrolidinyl]methoxy]-4-quinazolinyl]-3-methyl-1-piperazinyl]-

SMILES Code:

C=CC(N1C[C@H](C)N(C2=C3C=C(Cl)C(C4=NC(N))=CC(C)=C4C(F)(F)F)=C(F) )C3=NC(OC[C@H]5N(C)CCC5)=N2)CC1)=O

InChi Code:

InChI = 1S/C29H32ClF4N7O2/c1-5-21(42)40-9-10-41(16(3)13-40)27-18-12-19(30)22(26-23(29(32), 33) 34) 15(2) 11-20(35) 36-2 6) 24(31)25(18)37-28(38-27)43-14-17-7-6-8-39(17)4/h5,11-12,16-17H,1,6- 10,13-14H2,2-4H3,(H2,35,36)/t16-,17-/m0/s1

InChi Key:

ZRBPIAWRPFDPY-IRXDYDNUSA-N

Lo lus tseem ceeb:

2417917-17-8; CAS: 2417917-17-8; CAS: 2417917-17-8; GDC6036 atropisomers; GDC-6036; GDC 6036; wb 6036

Solubility: 

Cia:Qhuav, tsaus thiab ntawm 0 - 4 C rau lub sijhawm luv (hnub mus rau lub lis piam) lossis -20 C rau lub sijhawm ntev (hli mus rau xyoo).

Nqe lus piav qhia:

GDC6036 tiv thaiv kev sib hloov isomer muaj ob hom GDC6036 tiv thaiv kev sib hloov isomers. GDC-6036, Kuj hu ua RG6330, nws yog ib qho kev hais lus bioavailable, ua tau zoo, thiab xaiv KRAS G12C inhibitor.

Hom phiaj: KRAS G12C