Etoricoxib

Lub npe tshuaj:

5-Chloro-6'-methyl-3-[4-(methylsulfonyl)phenyl]-2,3'-bipyridine

SMILES Code:

O=S(C1=CC=C(C2=CC(Cl))=CN=C2C3=CC=C(C)N=C3)C=C1)(C)=O

InChi Code:

InChI = 1S/C18H15ClN2O2S/c1-12-3-4-14(10-20-12)18-17(9-15(19)11-21-18)13-5-7-16(8-6- 13) 24(2,22)23/h3-11H,1-2H3

InChi Key:

MNJVRJDLRVPLFE-UHFFFAOYSA-N

Lo lus tseem ceeb:

Etoricoxib, Arcoxia, L-791456, MK 0663, MK-0663, 202409-33-4

Solubility:Soluble hauv DMSO

Cia:0 - 4 ° C rau lub sijhawm luv (hnub mus rau lub lis piam), lossis -20 ° C rau lub sijhawm ntev (hli)

Nqe lus piav qhia:

Etoricoxib yog ib qho tshuaj hluavtaws, nonsteroidal anti-inflammatory tshuaj (NSAID) nrog antipyretic, analgesic, thiab muaj peev xwm antineoplastic zog. Etoricoxib tshwj xeeb khi rau thiab inhibits enzyme cyclooxygenase-2 (COX-2), uas ua rau inhibition ntawm kev hloov pauv ntawm arachidonic acid rau hauv prostaglandins. Inhibition ntawm COX-2 tuaj yeem ua rau apoptosis thiab inhibit qog cell proliferation thiab angiogenesis.

Hom phiaj: COX-2