IB 104

Lub npe tshuaj:

(2-(6-(2-(4-cyclopropylpyrimidin-5-yl)-4-fluorophenoxy)-1,2,4-triazin-5-yl)-2,7-diazaspiro[3.5]nonan-7-yl )((1S,3aR,6aS)-octahydrocyclopenta[c]pyrrol-1-yl)methanone

SMILES Code:

[H][C@@]12CCC[C@]1([H])[C@H](NC2)C(=O)N3CCC4(CN(C4)C5=C(OC6=CC=C(F)) C=C6C7=CN=CN=C7C8CC8)N=NC=N5)CC3

InChi Code:

1S/C31H35FN8O2/c32-21-6-7-25(23(12-21)24-14-33-17-35-26(24)19-4-5-19)42-29-28(36- 18-37-38-29) 40-15-31(16-40)8-1 0-39(11-9-31)30(41)27-22-3-1-2-20(22)13-34-27/h6-7,12,14,17-20,22,27, ib. 34H,1-5,8-11,13,15-16H2/t20-,22-,27-/m0/s1

InChi Key:

XDXAYPYOHXUEAM-CLHVYKLBSA-N

Lo lus tseem ceeb:

2938995-50-5 ; CAS : 2938995-50-5 ; CAS : 2938995-50-5 ; BN-104 ; BN 104 ; BN 104

Solubility: 

Cia:Qhuav, tsaus thiab ntawm 0 -4 C rau lub sijhawm luv (hnub mus rau lub lis piam) lossis -20 C rau lub sijhawm ntev (hli mus rau xyoo)

Nqe lus piav qhia:

BN-104 (BNM-1192) tuaj yeem tiv thaiv Menin MLL kev sib cuam tshuam thiab tuaj yeem siv rau hauv kev tshawb fawb qog noj ntshav, xws li mob qog noj ntshav myeloid leukemia.

Hom phiaj: Menin-MLL