TIAB SA - 2852

Lub npe tshuaj:

(S)-5-hydroxy-3-(2-((((1-((1-methyl-1H-imidazol-4-yl)methyl)-1H-indol-6-yl)methyl)amino)methyl) -1H-indol-3-yl)isoindolin-1-ib

SMILES Code:

OC(C=C1)=CC([C@@H](C2=C(CNCC3=CC4=C(C=CN4CC5=CN(C)C=N5)C=C3)NC6=CC=CC=C62) N7)=C1C7=O

InChi Code:

InChI = 1S/C31H28N6O2/c1-36-16-21(33-18-36)17-37-11-10-20-7-6-19(12-28(20)37)14-32-15- 27-29(24-4-2-3-5-26(24)34-27)30-25-13-22(38)8-9-23(25)31(39)35-30/h2- 13,16,18,30,32,34,38H,14-15,17H2,1H3,(H,35,39)/t30-/m0/s1

InChi Key:

JYEQLXOWWLNVDX-PMERELPUSA-N

Lo lus tseem ceeb:

Solubility: 

Cia: 

Nqe lus piav qhia:

BI-2852 yog ib qho muaj zog KRAS inhibitor uas khi nrog nanomolar affinity rau lub hnab tshos, kom deb li deb pom tau tias yog "tsis tuaj yeem," ntawm kev hloov kuv thiab II ntawm RAS. BI-2852 yog qhov sib txawv ntawm cov khoom sib txawv ntawm covalent KRASG12C inhibitors vim nws khi rau ib lub hnab tsho sib txawv tam sim no hauv ob qho tib si nquag thiab tsis ua haujlwm ntawm KRAS. BI-2852 blocks GEF, GAP, thiab cuam tshuam nrog KRAS, ua rau inhibition ntawm downstream signaling thiab antiproliferative nyhuv hauv KRAS mutant hlwb.

Hom phiaj: KRAS