Zidesamtinib; NVL-520

Chemical Name:

(6R)-22-ethyl-54-fluoro-42,6-dimethyl-22H,42 H-7-oxa1(3,5)-pyridina-2(3,4)-pyrazola-4(4,5)-[1,2,3]triazola5(1,2)-benzenacycloheptaphan-16-amine

SMILES Code: 

FC1=CC([C@](OC2=C(N=CC3=C2)N)(C)[H])=C(C=C1)C4=NN(N=C4CC5=C3N(N=C5)CC)C

InChi Code:

InChI=1S/C22H22FN7O/c1-4-30-21-13(11-26-30)7-18-20(28-29(3)27-18)16-6-5-15(23)9-17(16)12(2)31-19-8-14(21)10-25-22(19)24/h5-6,8-12H,4,7H2,1-3H3,(H2,24,25)/t12-/m1/s1

InChi Key:

DTWUUAFTYSMNQX-GFCCVEGCSA-N

Keyword:

2739829-00-4；CAS：2739829-00-4；CAS:2739829-00-4；Zidesamtinib; NVL-520; NVL520; NVL 520

Solubility: 

Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Description: 

Zidesamtinib (NVL-520) is an effective, selective, orally active, and blood-brain barrier permeable ROS1 fusion and resistance mutation inhibitor.

Target: ROS1