THZ2

THZ2
  • Name: THZ2
  • Catalog No.: CPDB1587
  • CAS No.: 1604810-84-5
  • Molecular Weight: 566.06
  • Chemical Formula: C31H28ClN7O2
  • For scientific research only, not for patients.

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    Chemical Name:

    N-[3-[[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]phenyl]-3-[[(E)-4-(dimethylamino)but-2-enoyl]amino]benzamide

    SMILES Code: 

    O=C(NC1=CC=CC(NC2=NC=C(Cl)C(C3=CNC4=C3C=CC=C4)=N2)=C1)C5=CC=CC(NC(/C=C/CN(C)C)=O)=C5

    InChi Code:

    InChI=1S/C31H28ClN7O2/c1-39(2)15-7-14-28(40)35-21-9-5-8-20(16-21)30(41)36-22-10-6-11-23(17-22)37-31-34-19-26(32)29(38-31)25-18-33-27-13-4-3-12-24(25)27/h3-14,16-19,33H,15H2,1-2H3,(H,35,40)(H,36,41)(H,34,37,38)/b14-7+

    InChi Key:

    FONRCZUZCHXWBD-VGOFMYFVSA-N

    Keyword:

    THZ-2, THZ 2, THZ2, 1604810-84-5

    Solubility: Soluble in DMSO

    Storage: 0 - 4°C for short term (days to weeks), or -20°C for long term (months).

    Description: 

    THZ2, an analog of THZ1, with the potential to treat Triple-negative breast cancer (TNBC), it is a potent and selective CDK7 inhibitor which overcomes the instability of THZ1 in vivo. IC50: CDK7= 13.9 nM; TNBC cells= 10 nM

    Target: CDK


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