S-600918，Sivopixant

Chemical Name:

(2S)-3-[(4E)-3-[(4-chlorophenyl)methyl]-2,6-dioxo-4-({4-[(pyridin-2-yl)oxy]phenyl}imino)-1,3,5-triazinan-1-yl]-2-methylpropanoic acid

SMILES Code: 

O=C(O)[C@@H](C)CN1C(N(CC2=CC=C(Cl)C=C2)/C(NC1=O)=N/C3=CC=C(OC4=NC=CC=C4)C=C3)=O

InChi Code:

InChI=1S/C25H22ClN5O5/c1-16(22(32)33)14-31-24(34)29-23(30(25(31)35)15-17-5-7-18(26)8-6-17)28-19-9-11-20(12-10-19)36-21-4-2-3-13-27-21/h2-13,16H,14-15H2,1H3,(H,32,33)(H,28,29,34)/t16-/m0/s1

InChi Key:

SKZQFKBIJUXXCG-INIZCTEOSA-N

Keyword:

2414285-40-6; CAS:2414285-40-6; CAS：2414285-40-6; Sivopixant; S-600918; S 600918; S600918

Solubility: Soluble in DMSO

Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years)

Description: 

Sivopixant, also known as S-600918, is a selective P2X3 receptor antagonist (P2X3 IC50, 4.2 nM; P2X2/3 IC50, 1100 nM). Sivopixant showed a strong analgesic effect in the rat partial sciatic nerve ligation model (Seltzer model) of allodynia (ED50, 0.4 mg/kg).

Target: Selective P2X3 receptor antagonist