Riviciclib

Riviciclib
  • Name: Riviciclib
  • Catalog No.: CPD100907
  • CAS No.: 920113-03-7 (HCl) 920113-02-6 (free base)
  • Molecular Weight: 401.103
  • Chemical Formula: C21H21Cl2NO5
  • For scientific research only, not for patients.

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    Chemical Name:

    2-(2-chlorophenyl)-5,7-dihydroxy-8-((2R,3S)-2-(hydroxymethyl)-1-methylpyrrolidin-3-yl)-4H-chromen-4-one hydrochloride

    SMILES Code: 

    O=C1C=C(C2=CC=CC=C2Cl)OC3=C1C(O)=CC(O)=C3[C@H]4[C@H](CO)N(C)CC4.[H]Cl

    InChi Code:

    InChI=1S/C21H20ClNO5.ClH/c1-23-7-6-12(14(23)10-24)19-15(25)8-16(26)20-17(27)9-18(28-21(19)20)11-4-2-3-5-13(11)22;/h2-5,8-9,12,14,24-26H,6-7,10H2,1H3;1H/t12-,14+;/m1./s1

    InChi Key:

    OOVTUOCTLAERQD-OJMBIDBESA-N

    Keyword:

    P276-00; P-276-00; P 276-00; P-27600; P 27600; P 27600; Riviciclib, Riviciclib HCl

    Solubility: 

    Storage: 

    Description: 

    Riviciclib, also known as P276-00 , is a flavone and cyclin dependent kinase (CDK) inhibitor with potential antineoplastic activity. P276-00 selectively binds to and inhibits Cdk4/cyclin D1, Cdk1/cyclin B and Cdk9/cyclin T1, serine/threonine kinases that play key roles in the regulation of the cell cycle and cellular proliferation. Inhibition of these kinases leads to cell cycle arrest during the G1/S transition, thereby leading to an induction of apoptosis, and inhibition of tumor cell proliferation.

    Target: CDK


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