MC180295

MC180295
  • Name: MC180295
  • Catalog No.: CPD100908
  • CAS No.: 2237942-08-2
  • Molecular Weight: 358.11
  • Chemical Formula: C17H18N4O3S
  • For scientific research only, not for patients.

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    Chemical Name:

    Rel-(4-amino-2-(((2S)-bicyclo[2.2.1]heptan-2-yl)amino)thiazol-5-yl)(2-nitrophenyl)methanone

    SMILES Code: 

    O=C(C1=C(N)N=C(N[C@@H]2C(C3)CCC3C2)S1)C4=CC=CC=C4[N+]([O-])=O

    InChi Code:

    InChI=1S/C17H18N4O3S/c18-16-15(14(22)11-3-1-2-4-13(11)21(23)24)25-17(20-16)19-12-8-9-5-6-10(12)7-9/h1-4,9-10,12H,5-8,18H2,(H,19,20)/t9?,10?,12-/m0/s1

    InChi Key:

    JRNXAQINDCOHGS-CBINBANVSA-N

    Keyword:

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    Description: 

    MC180295 is a highly selective CDK9 inhibitor (IC50 = 5 nM). (MC180295 has broad anti-cancer activity in vitro and is effective in in vivo cancer models. Additionally, CDK9 inhibition sensitizes to the immune checkpoint inhibitor α-PD-1 in vivo, making it an excellent target for epigenetic therapy of cancer.

    Target: CDK9


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