Ingliforib

Chemical Name:

5-chloro-N-((2S,3R)-4-((3S,4R)-3,4-dihydroxypyrrolidin-1-yl)-3-hydroxy-4-oxo-1-phenylbutan-2-yl)-1H-indole-2-carboxamide

SMILES Code: 

O[C@H](C1)[C@@H](O)CN1C([C@H](O)[C@H](CC2=CC=CC=C2)NC(C3=CC4=C(N3)C=CC(Cl)=C4)=O)=O

InChi Code:

InChI=1S/C23H24ClN3O5/c24-15-6-7-16-14(9-15)10-18(25-16)22(31)26-17(8-13-4-2-1-3-5-13)21(30)23(32)27-11-19(28)20(29)12-27/h1-7,9-10,17,19-21,25,28-30H,8,11-12H2,(H,26,31)/t17-,19-,20+,21+/m0/s1

InChi Key:

GVDRRZOORHCTAN-MJUUVYJYSA-N

Keyword:

Ingliforib; CP-296; CP-368; CP-368,296; CP296; CP 296; CP-368296; CP368296; CP 368296

Solubility: DMSO

Storage: 

Description: 

Ingliforib, also known as CP-368296, is a novel glycogen phosphorylase inhibitor. Ingliforib has antihyperglycemic and cardioprotective properties. Ingliforib inhibits glycogen phosphorylase, the rate-limiting enzyme in glycogenolysis, thereby preventing the release of glucose-1 phosphate from a glycogen molecule in liver. This agent also inhibits glycogen phosphorylase in cardiac muscle and may protect the heart from myocardial ischemic injury by preserving glycogen content and improving glycolytic-oxidative coupling

Target: glycogen phosphorylase