GSK2982772

GSK2982772
  • Name: GSK2982772
  • Catalog No.: CPDD1123
  • CAS No.: 1622848-92-3
  • Molecular Weight: 377.404
  • Chemical Formula: C20H19N5O3
  • For scientific research only, not for patients.

    Product Detail

    Product Tags

    Pack Size Availability Price (USD)
    100mg In Stock 500
    500mg In Stock 800
    1g In Stock 1200
    More Sizes Get Quotes Get Quotes

    Chemical Name:

    (S)-5-Benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydrobenzo[b]-[1,4]oxazepin-3-yl)-4H-1,2,4-triazole-3-carboxamide

    SMILES Code: 

    O=C(C1=NN=C(CC2=CC=CC=C2)N1)N[C@@H]3C(N(C)C4=CC=CC=C4OC3)=O

    InChi Code:

    InChI=1S/C20H19N5O3/c1-25-15-9-5-6-10-16(15)28-12-14(20(25)27)21-19(26)18-22-17(23-24-18)11-13-7-3-2-4-8-13/h2-10,14H,11-12H2,1H3,(H,21,26)(H,22,23,24)/t14-/m0/s1

    InChi Key:

    LYPAFUINURXJSG-AWEZNQCLSA-N

    Keyword:

    GSK-2982772, GSK 2982772, GSK2982772, 1622848-92-3

    Solubility: Soluble in DMSO

    Storage: 0 - 4°C for short term (days to weeks), or -20°C for long term (months).

    Description: 

    GSK2982772 is a potent and selective receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate for the Treatment of Inflammatory Diseases. GSK2982772 is, currently in phase 2a clinical studies for psoriasis, rheumatoid arthritis, and ulcerative colitis. GSK2982772 potently binds to RIP1 with exquisite kinase specificity and has excellent activity in blocking many TNF-dependent cellular responses. RIP1 has emerged as an important upstream kinase that has been shown to regulate inflammation through both scaffolding and kinase specific functions.

    Target: RIP1


  • Previous:
  • Next:

  • Related Products

    
    WhatsApp Online Chat !