EED226

EED226
  • Name: EED226
  • Catalog No.: CPD1019
  • CAS No.: 2083627-02-3
  • Molecular Weight: 369.40
  • Chemical Formula: C17H15N5O3S
  • For scientific research only, not for patients.

    Product Detail

    Product Tags

    Pack Size Availability Price (USD)
    25mg In stock 300
    50mg In stock 500
    100mg In stock 800

    Chemical Name:

    N-(furan-2-ylmethyl)-8-(4-(methylsulfonyl)phenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine

    SMILES Code: 

    O=S(C1=CC=C(C2=CN=C(NCC3=CC=CO3)N4C2=NN=C4)C=C1)(C)=O

    InChi Code:

    InChI=1S/C17H15N5O3S/c1-26(23,24)14-6-4-12(5-7-14)15-10-19-17(22-11-20-21-16(15)22)18-9-13-3-2-8-25-13/h2-8,10-11H,9H2,1H3,(H,18,19)

    InChi Key:

    DYIRSNMPIZZNBK-UHFFFAOYSA-N

    Keyword:

    EED226, EED-226, EED 226, 2083627-02-3

    Solubility: Soluble in DMSO

    Storage: 0 - 4°C for short term (days to weeks), or -20°C for long term (months).

    Description: 

    EED226 is a highly potent, efficient and selective inhibitor of EZH2 and EZH1 evaluated against a broad range of epigenetic and non-epigenetic targets. It potently reduces global H3K27Me3 mark in cells and demonstrates selectively cell killing effects in cells carrying a heterozygous Y641N mutation. EED226 has moderate permeability as the measured in Caco-2 cells at A→B=3.0x10-6 cm/s, with an efflux ratio at 7.6[1].

    Target: EED226




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