BAY-1895344

Chemical Name:

(R)-3-methyl-4-(4-(1-methyl-1H-pyrazol-5-yl)-8-(1H-pyrazol-5-yl)-1,7-naphthyridin-2-yl)morpholine

SMILES Code: 

CN1N=CC=C1C2=CC(N3[C@H](C)COCC3)=NC4=C(C5=CC=NN5)N=CC=C24.[H]Cl

InChi Code:

InChI=1S/C20H21N7O.ClH/c1-13-12-28-10-9-27(13)18-11-15(17-5-8-23-26(17)2)14-3-6-21-20(19(14)24-18)16-4-7-22-25-16;/h3-8,11,13H,9-10,12H2,1-2H3,(H,22,25);1H/t13-;/m1./s1

InChi Key:

KWQNBYGUBHMRPY-BTQNPOSSSA-N

Keyword:

1876467-74-1；CAS:1876467-74-1；CAS：1876467-74-1；BAY-1895344, BAY1895344, BAY 1895344

Solubility: Soluble in DMSO

Storage: 0 - 4°C for short term (days to weeks), or -20°C for long term (months).

Description: 

BAY-1895344 is a selective ATR (ataxia-telangiectasia and Rad3 related protein) inhibitor that inhibits proliferation of a broad spectrum of human tumor cell lines (median IC50 = 78 nM). BAY-1895344 is developed for the treatment of patients with advanced solid tumors and lymphomas, and it is undergoing a phase I clinical trial of safety and tolerability for cancer patients.

Target: ATR