AZD8186

AZD8186
  • Name: AZD8186
  • Catalog No.: CPDB0202
  • CAS No.: 1627494-13-6
  • Molecular Weight: 457.4
  • Chemical Formula: C24H25F2N3O4
  • For scientific research only, not for patients.

    Product Detail

    Product Tags

    Pack Size Availability Price (USD)
    100mg In Stock 350
    500mg In Stock 700
    More Sizes Get Quotes Get Quotes

    Chemical Name:

    (R)-8-(1-((3,5-difluorophenyl)amino)ethyl)-N,N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide

    SMILES Code: 

    O=C(N(C)C)C1=CC([C@@H](C)NC2=CC(F)=CC(F)=C2)=C3C(C(C=C(O3)N4CCOCC4)=O)=C1

    InChi Code:

    InChI=1S/C24H25F2N3O4/c1-14(27-18-11-16(25)10-17(26)12-18)19-8-15(24(31)28(2)3)9-20-21(30)13-22(33-23(19)20)29-4-6-32-7-5-29/h8-14,27H,4-7H2,1-3H3/t14-/m1/s1

    InChi Key:

    LMJFJIDLEAWOQJ-CQSZACIVSA-N

    Keyword:

    AZD8186, AZD-8186, AZD 8186, 1627494-13-6

    Solubility: Soluble in DMSO

    Storage: 0 - 4°C for short term (days to weeks), or -20°C for long term (months)

    Description: 

    AZD8186 is and inhibitor of the beta isoform of phosphoinositide-3 kinase (PI3K), with potential antineoplastic activity. Upon administration, PI3Kbeta inhibitor AZD8186 selectively inhibits the activity of PI3Kbeta in the PI3K/Akt/mTOR signaling pathway, which may result in a decrease of tumor cell proliferation. It also induces cell death in PI3K-expressing cancer cells. By specifically targeting class I PI3K beta, this agent may be more efficacious and less toxic than pan PI3K inhibitors. PI3K-mediated signaling is often dysregulated in cancer cells and contributes to increased tumor cell growth, survival, and tumor resistance to a variety of antineoplastic agents. AZD8186 is currently under Phase I clinical trials.

    Target: PI3K


  • Previous:
  • Next:

  • Related Products

    
    WhatsApp Online Chat !