APOL1-IN-1

Chemical Name:

3-(2-(4-fluorophenyl)-1H-indol-3-yl)-N-((3R,4S)-4-hydroxy-2-oxopyrrolidin-3-yl)propanamide

SMILES Code: 

O[C@H]1CNC([C@@H]1NC(CCC2=C(C3=CC=C(F)C=C3)NC4=C2C=CC=C4)=O)=O

InChi Code:

InChI=1S/C21H20FN3O3/c22-13-7-5-12(6-8-13)19-15(14-3-1-2-4-16(14)24-19)9-10-18(27)25-20-17(26)11-23-21(20)28/h1-8,17,20,24,26H,9-11H2,(H,23,28)(H,25,27)/t17-,20+/m0/s1

InChi Key:

CNYZYDUBGMRAFP-FXAWDEMLSA-N

Keyword:

2446817-72-5；CAS:2446817-72-5；CAS：2446817-72-5

Solubility: 

Storage: 

Description: 

Kif18a-in-1 is an inhibitor of APOL1 APOL1, which can be used in the study of focal segmental glomerulosclerosis (FSGS) and non diabetes nephropathy (ndkd). For details, please refer to compound 87 in patent document wo2020131807a1.

Target: Inhibitor of apolipoprotein L1 APOL1