Afatinib dimaleate

Chemical Name:

(S,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide dimaleate

SMILES Code: 

O=C(NC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1O[C@@H]4COCC4)/C=C/CN(C)C.O=C(O)/C=CC(O)=O.O=C(O)/C=CC(O)=O

InChi Code:

InChI=1S/C24H25ClFN5O3.2C4H4O4/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15;2*5-3(6)1-2-4(7)8/h3-6,10-12,14,16H,7-9,13H2,1-2H3,(H,30,32)(H,27,28,29);2*1-2H,(H,5,6)(H,7,8)/b4-3+;2*2-1-/t16-;;/m0../s1

InChi Key:

USNRYVNRPYXCSP-JUGPPOIOSA-N

Keyword:

850140-73-7；CAS:850140-73-7；CAS：850140-73-7；Afatinib dimaleate；BIBW-2992；BIBW 2992；BIBW2992

Solubility: Soluble in DMSO, not in water

Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Description: 

Afatinib (BIBW 2992) dimerate is an orally effective and irreversible ErbB family (EGFR and HER2) bispecific inhibitor.

Target: EGFR and HER2