Luxdegalutamide; ARV-766

Chemical Name:

4-(4-((1-(4-(((1r,3r)-3-(4-cyano-3-methoxyphenoxy)-2,2,4,4-tetramethylcyclobutyl)carbamoyl)phenyl)piperidin-4-yl)methyl)piperazin-1-yl)-N-((S)-2,6-dioxopiperidin-3-yl)-2-fluorobenzamide

SMILES Code: 

CC1(C)[C@H](NC(C2=CC=C(N3CCC(CN4CCN(C5=CC(F)=C(C(N[C@@H]6C(=O)NC(=O)CC6)=O)C=C5)CC4)CC3)C=C2)=O)C(C)(C)[C@H]1OC1=CC(OC)=C(C#N)C=C1

InChi Code:

InChI=1S/C45H54FN7O6/c1-44(2)42(45(3,4)43(44)59-33-12-8-30(26-47)37(25-33)58-5)50-39(55)29-6-9-31(10-7-29)52-18-16-28(17-19-52)27-51-20-22-53(23-21-51)32-11-13-34(35(46)24-32)40(56)48-36-14-15-38(54)49-41(36)57/h6-13,24-25,28,36,42-43H,14-23,27H2,1-5H3,(H,48,56)(H,50,55)(H,49,54,57)/t36-,42-,43-/m0/s1

InChi Key:

RDPPBRKNBBXPNZ-FMPIRMQTSA-N

Keyword:

2750830-09-0；CAS：2750830-09-0；CAS:2750830-09-0；ARV766; ARV 766; ARV-766; GTPL12624; luxdegalutamide

Solubility: 

Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Description: 

Luxdegalutamide (ARV-766) is an orally effective protein hydrolysis targeted chimeric (PROTAC) targeting androgen receptor (AR), which can degrade AR resistance related mutants.

Target: AR